Scientific advances in the latter half of the twentieth century
have allowed researchers to study the chemical activities
taking place in the human brain during the sleep cycle in
more detail. In the 1970s, Jacobs employed these
advances to postulate that dreams and hallucinations share
a common neurochemical mechanism with respect to the
neurotransmitters serotonin and norepinephrine that
accounts for the observable similarities between the two
states of mind. To test the theory, researchers attempted
to elucidate the role of these transmitters in the normal
sleep cycle and the effect of hallucinogenic drugs on them.
Although scientists still have much to discover about the
chemical complexities of the brain, serotonin appears
important for managing sleep, mood, and appetite, among
other important functions, while neurons release
norepinephrine to facilitate alertness and mental focus.
Both are discharged in high quantities only during waking
states. At the onset of sleep, the activity levels of neurons
that release both the neurotransmitters drop, allowing
the brain first to enter the four non-rapid eye movement
(Non-REM) stages of sleep. When the brain is ready to
enter the fifth stage, REM, which is associated with
dreaming, the levels of these two chemicals drop virtually
to zero. The Jacobs hypothesis held that the absence of
norepinephrine was required to enable the brain to remain
asleep, while the absence of serotonin was necessary to
allow dreaming to occur.
Lysergic acid diethylamide, or LSD, is a semi-synthetic
psychedelic drug which causes significant alteration of
the senses, memories and awareness; at doses higher
than 20 micrograms, it can have a hallucinogenic effect.
LSD mimics serotonin well enough to be able to bind at
most of the neurotransmitter's receptor sites, largely
inhibiting normal transmission. In addition, the drug causes
the locus ceruleus, a cluster of neurons containing
norepinephrine, to greatly accelerate activity. If the drug
stimulates norepinephrine, thereby precluding sleep, and
inhibits serotonin, which Jacobs had postulated was a
necessary condition for dreaming, then the resulting
hallucinations could merely be "dreaming while awake."
The research thus far is promising but inconclusive; future
scientific advances should allow this theory to be tested
more rigorously.
1. Which of the following, if true, would most undermine
the central premise of the Jacobs hypothesis?
< LSD does not completely inhibit normal transmission
of serotonin.
< Serotonin is only one of many chemicals that play a
role in regulating sleep.
< Researchers prove conclusively that the level of
norepinephrine in the brain is a significant factor in
enabling the brain to sleep.
< Some semi-synthetic hallucinogenic drugs other than
LSD do not inhibit serotonin.
< The first four stages of sleep are as crucial to the
process of dreaming as the fifth stage.